Drug interactions
Bisoprolol + Rifampin
Severity: Minor
Bisoprolol and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces drug-metabolizing enzymes and may lower bisoprolol exposure. Bisoprolol is cleared about half by the kidneys, so the reduction is modest and usually of limited clinical importance.
What this interaction means in plain words
Bisoprolol and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of hepatic metabolism (CYP3A4) by rifampin increases clearance of the hepatically cleared portion of bisoprolol.
What to do
Monitor heart rate and blood pressure when rifampin is started or stopped, and increase the bisoprolol dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Rifampin?
MediHelp rates the interaction as minor. Bisoprolol and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin induces drug-metabolizing enzymes and may lower bisoprolol exposure. Bisoprolol is cleared about half by the kidneys, so the reduction is modest and usually of limited clinical importance.
How serious is the interaction between Bisoprolol and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when rifampin is started or stopped, and increase the bisoprolol dose if response is inadequate.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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