Drug interactions
Bisoprolol + Sacubitril / valsartan
Severity: Moderate
Bisoprolol and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are used together in heart failure, but together they can cause additive hypotension, dizziness and bradycardia. Sacubitril/valsartan may also raise serum potassium and affect renal function, while bisoprolol has little direct effect on potassium.
What this interaction means in plain words
Bisoprolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering; angiotensin receptor blockade also promotes potassium retention.
What to do
Monitor blood pressure, heart rate, serum potassium and creatinine, especially during initiation and dose titration. Adjust doses gradually if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Bisoprolol and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are used together in heart failure, but together they can cause additive hypotension, dizziness and bradycardia. Sacubitril/valsartan may also raise serum potassium and affect renal function, while bisoprolol has little direct effect on potassium.
How serious is the interaction between Bisoprolol and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, serum potassium and creatinine, especially during initiation and dose titration. Adjust doses gradually if hypotension occurs.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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