Drug interactions
Bisoprolol + Salsalate
Severity: Moderate
Bisoprolol and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that may reduce the blood pressure lowering of bisoprolol with regular use. It may also affect renal function and promote fluid retention.
What this interaction means in plain words
Bisoprolol and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition causes sodium and water retention, opposing the antihypertensive effect of bisoprolol.
What to do
Monitor blood pressure if salsalate is used regularly for more than a week. Use the lowest effective dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Salsalate?
MediHelp rates the interaction as moderate. Bisoprolol and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that may reduce the blood pressure lowering of bisoprolol with regular use. It may also affect renal function and promote fluid retention.
How serious is the interaction between Bisoprolol and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if salsalate is used regularly for more than a week. Use the lowest effective dose or an alternative analgesic.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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