Drug interactions
Bisoprolol + Sildenafil
Severity: Moderate
Bisoprolol and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil is a vasodilator and bisoprolol lowers blood pressure through beta-1 blockade. Combined use may cause an additive drop in blood pressure, occasionally causing symptomatic hypotension.
What this interaction means in plain words
Bisoprolol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive hypotensive effect of PDE5 inhibition-induced vasodilation and beta-blockade.
What to do
Use the lowest starting dose of sildenafil in patients stable on bisoprolol and monitor blood pressure after the first doses. Counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Sildenafil?
MediHelp rates the interaction as moderate. Bisoprolol and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil is a vasodilator and bisoprolol lowers blood pressure through beta-1 blockade. Combined use may cause an additive drop in blood pressure, occasionally causing symptomatic hypotension.
How serious is the interaction between Bisoprolol and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest starting dose of sildenafil in patients stable on bisoprolol and monitor blood pressure after the first doses. Counsel patients about orthostatic symptoms.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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