Drug interactions
Bisoprolol + Terbutaline
Severity: Moderate
Bisoprolol and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol can reduce the bronchodilator response to terbutaline and may provoke bronchospasm in patients with asthma or COPD. The risk is less than with non-selective beta-blockers but increases at higher bisoprolol doses.
What this interaction means in plain words
Bisoprolol and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors by a beta-1 selective blocker whose selectivity is dose-dependent.
What to do
Keep bisoprolol at the lowest effective dose in patients with airway disease and monitor respiratory symptoms and terbutaline response. Consider a non-beta-blocker alternative if bronchospasm occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bisoprolol and Terbutaline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Terbutaline
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Terbutaline?
MediHelp rates the interaction as moderate. Bisoprolol and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol can reduce the bronchodilator response to terbutaline and may provoke bronchospasm in patients with asthma or COPD. The risk is less than with non-selective beta-blockers but increases at higher bisoprolol doses.
How serious is the interaction between Bisoprolol and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep bisoprolol at the lowest effective dose in patients with airway disease and monitor respiratory symptoms and terbutaline response. Consider a non-beta-blocker alternative if bronchospasm occurs.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
