Drug interactions
Bisoprolol + Theophylline
Severity: Moderate
Bisoprolol and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol is highly beta-1 selective, so it has little effect on theophylline kinetics, but it may still blunt bronchodilation at higher doses. Patients with asthma or COPD may have worsened airflow.
What this interaction means in plain words
Bisoprolol and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Theophylline belongs to Respiratory.
Why it happens
Loss of cardioselectivity at higher doses leads to beta-2 blockade opposing theophylline's bronchodilation.
What to do
Keep the bisoprolol dose low and monitor respiratory symptoms and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Theophylline?
MediHelp rates the interaction as moderate. Bisoprolol and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol is highly beta-1 selective, so it has little effect on theophylline kinetics, but it may still blunt bronchodilation at higher doses. Patients with asthma or COPD may have worsened airflow.
How serious is the interaction between Bisoprolol and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bisoprolol dose low and monitor respiratory symptoms and heart rate.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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