Drug interactions
Bisoprolol + Yohimbe
Severity: Moderate
Bisoprolol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises sympathetic outflow, which can cause hypertension and tachycardia. Beta-blockers may blunt the tachycardia but would not reliably prevent the pressor effect, and the net result is unpredictable.
What this interaction means in plain words
Bisoprolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between yohimbine-induced sympathetic activation and beta-adrenergic blockade.
What to do
Advise against yohimbe use in patients on bisoprolol for hypertension or heart disease, and monitor blood pressure if it is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Yohimbe?
MediHelp rates the interaction as moderate. Bisoprolol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises sympathetic outflow, which can cause hypertension and tachycardia. Beta-blockers may blunt the tachycardia but would not reliably prevent the pressor effect, and the net result is unpredictable.
How serious is the interaction between Bisoprolol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against yohimbe use in patients on bisoprolol for hypertension or heart disease, and monitor blood pressure if it is used.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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