Drug interactions
Bivalirudin + Citalopram
Severity: Moderate
Bivalirudin and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and citalopram reduces platelet function. Combined use may increase the risk of bleeding.
What this interaction means in plain words
Bivalirudin and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis: SSRI-induced platelet dysfunction plus direct thrombin inhibition.
What to do
Monitor for bleeding at access sites and other locations during and after bivalirudin infusion. Follow hemoglobin and coagulation parameters as per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Bivalirudin with Citalopram?
MediHelp rates the interaction as moderate. Bivalirudin and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and citalopram reduces platelet function. Combined use may increase the risk of bleeding.
How serious is the interaction between Bivalirudin and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding at access sites and other locations during and after bivalirudin infusion. Follow hemoglobin and coagulation parameters as per protocol.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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