Drug interactions
Bivalirudin + Deferasirox
Severity: Moderate
Bivalirudin and Deferasirox: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has been associated with gastric ulceration and GI hemorrhage. Bivalirudin is a direct thrombin inhibitor that adds to the bleeding risk.
What this interaction means in plain words
Bivalirudin and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from deferasirox GI mucosal injury and anticoagulant effect.
What to do
Monitor for GI bleeding signs and hemoglobin. Consider gastroprotection in patients at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Frequently asked questions
Can I take Bivalirudin with Deferasirox?
MediHelp rates the interaction as moderate. Bivalirudin and Deferasirox can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox has been associated with gastric ulceration and GI hemorrhage. Bivalirudin is a direct thrombin inhibitor that adds to the bleeding risk.
How serious is the interaction between Bivalirudin and Deferasirox?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding signs and hemoglobin. Consider gastroprotection in patients at high risk.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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