Drug interactions
Bivalirudin + Ethinyl estradiol-levonorgestrel
Severity: Minor
Bivalirudin and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined hormonal contraceptives increase thrombotic risk, while bivalirudin is used to prevent thrombosis during procedures. No direct pharmacokinetic interaction is expected, and bivalirudin's short half-life limits any overlap.
What this interaction means in plain words
Bivalirudin and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Estrogen's prothrombotic effect theoretically opposes direct thrombin inhibition, though bivalirudin acts only briefly.
What to do
No routine action is needed for procedural use. Review the ongoing need for estrogen-containing contraception in patients with thrombotic disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Bivalirudin with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Bivalirudin and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combined hormonal contraceptives increase thrombotic risk, while bivalirudin is used to prevent thrombosis during procedures. No direct pharmacokinetic interaction is expected, and bivalirudin's short half-life limits any overlap.
How serious is the interaction between Bivalirudin and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for procedural use. Review the ongoing need for estrogen-containing contraception in patients with thrombotic disease.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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