Drug interactions
Bivalirudin + Fenoprofen
Severity: Moderate
Bivalirudin and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bivalirudin is a direct thrombin inhibitor, and fenoprofen reduces platelet aggregation and can cause gastrointestinal lesions. Concurrent use may increase the risk of bleeding.
What this interaction means in plain words
Bivalirudin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on hemostasis: direct thrombin inhibition plus NSAID antiplatelet activity.
What to do
Monitor for bleeding and coagulation parameters during bivalirudin therapy. Avoid starting an NSAID during the procedure unless essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Bivalirudin with Fenoprofen?
MediHelp rates the interaction as moderate. Bivalirudin and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bivalirudin is a direct thrombin inhibitor, and fenoprofen reduces platelet aggregation and can cause gastrointestinal lesions. Concurrent use may increase the risk of bleeding.
How serious is the interaction between Bivalirudin and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters during bivalirudin therapy. Avoid starting an NSAID during the procedure unless essential.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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