Drug interactions
Bivalirudin + Fish oil
Severity: Moderate
Bivalirudin and Fish oil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids have mild antiplatelet effects and bivalirudin is a direct thrombin inhibitor. The combination may modestly increase bleeding risk.
What this interaction means in plain words
Bivalirudin and Fish oil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis from platelet inhibition and direct thrombin inhibition.
What to do
Monitor for bleeding at access sites and other bleeding signs during bivalirudin use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fish oil
- Antithrombin alfa + Fish oil Moderate
- Antithrombin iii + Fish oil Moderate
- Aspirin / citric acid / sodium bicarbonate + Fish oil Moderate
- Aspirin + Fish oil Moderate
- Betrixaban + Fish oil Moderate
- Dabigatran + Fish oil Moderate
Frequently asked questions
Can I take Bivalirudin with Fish oil?
MediHelp rates the interaction as moderate. Bivalirudin and Fish oil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omega-3 fatty acids have mild antiplatelet effects and bivalirudin is a direct thrombin inhibitor. The combination may modestly increase bleeding risk.
How serious is the interaction between Bivalirudin and Fish oil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding at access sites and other bleeding signs during bivalirudin use.
What other medicines interact with Fish oil?
MediHelp also lists interactions of Fish oil with, for example, Antithrombin alfa, Antithrombin iii, Aspirin / citric acid / sodium bicarbonate. The full list is on the Fish oil page.
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