Drug interactions
Bivalirudin + Fluorouracil
Severity: Moderate
Bivalirudin and Fluorouracil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluorouracil can cause thrombocytopenia, and bivalirudin is a direct thrombin inhibitor. Combined use raises the risk of bleeding.
What this interaction means in plain words
Bivalirudin and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia plus anticoagulation.
What to do
Check platelet counts before and during bivalirudin use and monitor for bleeding; adjust anticoagulation if platelets are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluorouracil
Frequently asked questions
Can I take Bivalirudin with Fluorouracil?
MediHelp rates the interaction as moderate. Bivalirudin and Fluorouracil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluorouracil can cause thrombocytopenia, and bivalirudin is a direct thrombin inhibitor. Combined use raises the risk of bleeding.
How serious is the interaction between Bivalirudin and Fluorouracil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check platelet counts before and during bivalirudin use and monitor for bleeding; adjust anticoagulation if platelets are low.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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