Drug interactions
Bivalirudin + Hydrocortisone
Severity: Minor
Bivalirudin and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may promote mucosal injury and vascular fragility, which could add modestly to the bleeding risk of a direct thrombin inhibitor. No reliable pharmacokinetic interaction is established.
What this interaction means in plain words
Bivalirudin and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive pharmacodynamic effect on bleeding risk; no established mechanism of direct interaction.
What to do
Monitor for bleeding and use activated clotting time or aPTT as appropriate for bivalirudin; INR is not the relevant test. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Bivalirudin with Hydrocortisone?
MediHelp rates the interaction as minor. Bivalirudin and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may promote mucosal injury and vascular fragility, which could add modestly to the bleeding risk of a direct thrombin inhibitor. No reliable pharmacokinetic interaction is established.
How serious is the interaction between Bivalirudin and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and use activated clotting time or aPTT as appropriate for bivalirudin; INR is not the relevant test. No dose change is routinely needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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