Drug interactions
Bretylium + Hydrochlorothiazide-olmesartan
Severity: Moderate
Bretylium and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium commonly causes hypotension through adrenergic neuron blockade, and the thiazide and angiotensin receptor blocker in this combination product also lower blood pressure. Together they may produce additive or excessive hypotension, particularly on standing.
What this interaction means in plain words
Bretylium and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic blood pressure lowering through sympathetic blockade, volume depletion and angiotensin receptor blockade.
What to do
Monitor blood pressure closely, including orthostatic readings, when bretylium is given. Reduce or hold the antihypertensive combination if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Bretylium with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Bretylium and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium commonly causes hypotension through adrenergic neuron blockade, and the thiazide and angiotensin receptor blocker in this combination product also lower blood pressure. Together they may produce additive or excessive hypotension, particularly on standing.
How serious is the interaction between Bretylium and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely, including orthostatic readings, when bretylium is given. Reduce or hold the antihypertensive combination if hypotension develops.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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