Drug interactions
Bretylium + Olmesartan
Severity: Moderate
Bretylium and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower blood pressure, and bretylium can cause orthostatic hypotension through adrenergic neuron blockade. Combined use may produce additive hypotension, with dizziness or fainting especially on standing.
What this interaction means in plain words
Bretylium and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from angiotensin receptor blockade and adrenergic neuron blockade.
What to do
Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the olmesartan dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Bretylium with Olmesartan?
MediHelp rates the interaction as moderate. Bretylium and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower blood pressure, and bretylium can cause orthostatic hypotension through adrenergic neuron blockade. Combined use may produce additive hypotension, with dizziness or fainting especially on standing.
How serious is the interaction between Bretylium and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including standing readings, when starting or adjusting either drug. Reduce the olmesartan dose if symptomatic hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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