Drug interactions
Brexanolone + Clemastine
Severity: Moderate
Brexanolone and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone commonly causes excessive sedation and sudden loss of consciousness, and a sedating antihistamine may add to these effects. The infusion is given under monitoring because of this risk.
What this interaction means in plain words
Brexanolone and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression: brexanolone positively modulates GABA-A receptors while clemastine blocks central H1 receptors.
What to do
Monitor continuously for sedation and oxygen saturation during the infusion as required by labeling. Consider holding clemastine or other sedatives if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Frequently asked questions
Can I take Brexanolone with Clemastine?
MediHelp rates the interaction as moderate. Brexanolone and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone commonly causes excessive sedation and sudden loss of consciousness, and a sedating antihistamine may add to these effects. The infusion is given under monitoring because of this risk.
How serious is the interaction between Brexanolone and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and oxygen saturation during the infusion as required by labeling. Consider holding clemastine or other sedatives if excessive sedation occurs.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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