Drug interactions
Brexanolone + Doxylamine
Severity: Major
Brexanolone and Doxylamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes excessive sedation and sudden loss of consciousness in some patients. Adding doxylamine can increase the risk and depth of sedation.
What this interaction means in plain words
Brexanolone and Doxylamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression; brexanolone is a GABA-A positive modulator and doxylamine blocks H1 receptors centrally.
What to do
Monitor continuously for sedation and hypoxia during the infusion as required by labeling. Avoid doxylamine and reduce or hold other CNS depressants if sedation occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Doxylamine
Frequently asked questions
Can I take Brexanolone with Doxylamine?
MediHelp rates the interaction as major. Brexanolone and Doxylamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness in some patients. Adding doxylamine can increase the risk and depth of sedation.
How serious is the interaction between Brexanolone and Doxylamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion as required by labeling. Avoid doxylamine and reduce or hold other CNS depressants if sedation occurs.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Doxylamine page.
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