Drug interactions
Brexanolone + Lamotrigine
Severity: Moderate
Brexanolone and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and can cause sudden loss of consciousness. Lamotrigine may add to these effects.
What this interaction means in plain words
Brexanolone and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Monitor sedation and oxygen saturation continuously during the infusion as required by labeling. Reduce or interrupt the brexanolone infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Frequently asked questions
Can I take Brexanolone with Lamotrigine?
MediHelp rates the interaction as moderate. Brexanolone and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and can cause sudden loss of consciousness. Lamotrigine may add to these effects.
How serious is the interaction between Brexanolone and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the infusion as required by labeling. Reduce or interrupt the brexanolone infusion if excessive sedation occurs.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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