Drug interactions
Brexanolone + Olanzapine
Severity: Moderate
Brexanolone and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and sudden loss of consciousness, and other CNS depressants may increase this risk. Olanzapine adds to the sedative load.
What this interaction means in plain words
Brexanolone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A positive modulation and antipsychotic sedation.
What to do
Monitor sedation and oxygen saturation continuously during the brexanolone infusion. Reduce or interrupt the infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexanolone and Olanzapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olanzapine
Frequently asked questions
Can I take Brexanolone with Olanzapine?
MediHelp rates the interaction as moderate. Brexanolone and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and sudden loss of consciousness, and other CNS depressants may increase this risk. Olanzapine adds to the sedative load.
How serious is the interaction between Brexanolone and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the brexanolone infusion. Reduce or interrupt the infusion if excessive sedation occurs.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
