Drug interactions
Brexanolone + Pimozide
Severity: Moderate
Brexanolone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and sudden loss of consciousness, and pimozide adds CNS depression. The combination may intensify drowsiness and impair alertness.
What this interaction means in plain words
Brexanolone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A modulation and antipsychotic sedation.
What to do
Monitor sedation and oxygen saturation during the infusion, and reduce or interrupt the brexanolone dose if excessive sedation occurs. Ensure continuous observation as required by labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Brexanolone with Pimozide?
MediHelp rates the interaction as moderate. Brexanolone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and sudden loss of consciousness, and pimozide adds CNS depression. The combination may intensify drowsiness and impair alertness.
How serious is the interaction between Brexanolone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation during the infusion, and reduce or interrupt the brexanolone dose if excessive sedation occurs. Ensure continuous observation as required by labeling.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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