Drug interactions
Brivaracetam + Buprenorphine long-acting
Severity: Moderate
Brivaracetam and Buprenorphine long-acting: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine and brivaracetam both cause CNS depression, so combined use can increase drowsiness and dizziness. Respiratory depression is possible, and the long-acting injection cannot be quickly withdrawn.
What this interaction means in plain words
Brivaracetam and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for sedation and respiratory depression, particularly when brivaracetam is started or increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Buprenorphine long-acting?
MediHelp rates the interaction as moderate. Brivaracetam and Buprenorphine long-acting can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine and brivaracetam both cause CNS depression, so combined use can increase drowsiness and dizziness. Respiratory depression is possible, and the long-acting injection cannot be quickly withdrawn.
How serious is the interaction between Brivaracetam and Buprenorphine long-acting?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, particularly when brivaracetam is started or increased.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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