Drug interactions
Brivaracetam + Buprenorphine
Severity: Moderate
Brivaracetam and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and impaired coordination, and the combined effect is additive. Clinically important respiratory depression is uncommon but possible.
What this interaction means in plain words
Brivaracetam and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Buprenorphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Monitor for sedation and dizziness, particularly at initiation or dose increases. Counsel patients on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Buprenorphine?
MediHelp rates the interaction as moderate. Brivaracetam and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, dizziness and impaired coordination, and the combined effect is additive. Clinically important respiratory depression is uncommon but possible.
How serious is the interaction between Brivaracetam and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, particularly at initiation or dose increases. Counsel patients on driving and alcohol.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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