Drug interactions
Brivaracetam + Clemastine
Severity: Moderate
Brivaracetam and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness. Taken together, sedation and impaired psychomotor performance may be more pronounced, raising the risk of falls and accidents.
What this interaction means in plain words
Brivaracetam and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brivaracetam belongs to Central Nervous System; Clemastine belongs to Respiratory.
Why it happens
Additive central nervous system depression from brivaracetam and the sedating first-generation antihistamine clemastine.
What to do
Counsel patients about additive drowsiness and advise against driving or operating machinery until the response is known. Consider a non-sedating antihistamine if sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Clemastine
Frequently asked questions
Can I take Brivaracetam with Clemastine?
MediHelp rates the interaction as moderate. Brivaracetam and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness. Taken together, sedation and impaired psychomotor performance may be more pronounced, raising the risk of falls and accidents.
How serious is the interaction between Brivaracetam and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and advise against driving or operating machinery until the response is known. Consider a non-sedating antihistamine if sedation becomes troublesome.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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