Drug interactions
Brivaracetam + Fentanyl transdermal
Severity: Moderate
Brivaracetam and Fentanyl transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can deepen drowsiness, impair psychomotor performance and, in vulnerable patients, add to respiratory depression. The risk is greatest at initiation and after dose increases.
What this interaction means in plain words
Brivaracetam and Fentanyl transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from the opioid and the antiseizure drug.
What to do
Use the lowest effective doses and monitor for excessive sedation and respiratory depression, particularly during titration. Counsel patients to avoid driving and other hazardous tasks until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Fentanyl transdermal?
MediHelp rates the interaction as moderate. Brivaracetam and Fentanyl transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can deepen drowsiness, impair psychomotor performance and, in vulnerable patients, add to respiratory depression. The risk is greatest at initiation and after dose increases.
How serious is the interaction between Brivaracetam and Fentanyl transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation and respiratory depression, particularly during titration. Counsel patients to avoid driving and other hazardous tasks until the response is known.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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