Drug interactions
Brivaracetam + Fexinidazole
Severity: Minor
Brivaracetam and Fexinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brivaracetam is partly cleared by CYP2C19 hydroxylation, and fexinidazole or its metabolites may inhibit some CYP enzymes. Brivaracetam exposure might therefore rise, but the effect has not been clearly characterized.
What this interaction means in plain words
Brivaracetam and Fexinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2C19-mediated brivaracetam metabolism; not well established clinically.
What to do
Monitor for increased somnolence or dizziness during the short fexinidazole course. Reduce the brivaracetam dose only if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Fexinidazole?
MediHelp rates the interaction as minor. Brivaracetam and Fexinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brivaracetam is partly cleared by CYP2C19 hydroxylation, and fexinidazole or its metabolites may inhibit some CYP enzymes. Brivaracetam exposure might therefore rise, but the effect has not been clearly characterized.
How serious is the interaction between Brivaracetam and Fexinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased somnolence or dizziness during the short fexinidazole course. Reduce the brivaracetam dose only if adverse effects occur.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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