Drug interactions
Brivaracetam + Flurazepam
Severity: Moderate
Brivaracetam and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taken together they can increase drowsiness, dizziness and impaired psychomotor performance. Elderly patients and those driving or operating machinery are at greater risk.
What this interaction means in plain words
Brivaracetam and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through different pharmacodynamic pathways (SV2A modulation and GABA-A potentiation).
What to do
Monitor for excessive sedation and falls, especially when starting or increasing either drug. Use the lowest effective flurazepam dose and counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Flurazepam?
MediHelp rates the interaction as moderate. Brivaracetam and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taken together they can increase drowsiness, dizziness and impaired psychomotor performance. Elderly patients and those driving or operating machinery are at greater risk.
How serious is the interaction between Brivaracetam and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, especially when starting or increasing either drug. Use the lowest effective flurazepam dose and counsel patients about driving.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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