Drug interactions
Brivaracetam + Levorphanol
Severity: Moderate
Brivaracetam and Levorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as levorphanol cause sedation and respiratory depression, and brivaracetam adds to CNS depression. The combination may increase drowsiness and, at higher doses, impair breathing.
What this interaction means in plain words
Brivaracetam and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from mu-opioid agonism and brivaracetam's neurological effects.
What to do
Start with low opioid doses and titrate gradually while monitoring sedation and respiratory rate. Counsel patients to avoid alcohol and other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Levorphanol?
MediHelp rates the interaction as moderate. Brivaracetam and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as levorphanol cause sedation and respiratory depression, and brivaracetam adds to CNS depression. The combination may increase drowsiness and, at higher doses, impair breathing.
How serious is the interaction between Brivaracetam and Levorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low opioid doses and titrate gradually while monitoring sedation and respiratory rate. Counsel patients to avoid alcohol and other depressants.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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