Drug interactions
Brivaracetam + Meprobamate
Severity: Moderate
Brivaracetam and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative anxiolytic that depresses the CNS, and brivaracetam can cause somnolence and dizziness. Combined use may cause marked drowsiness and impaired coordination.
What this interaction means in plain words
Brivaracetam and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; meprobamate has GABA-A related sedative action while brivaracetam binds SV2A.
What to do
Monitor for oversedation and psychomotor impairment, particularly in older adults. Use the lowest effective meprobamate dose and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Meprobamate?
MediHelp rates the interaction as moderate. Brivaracetam and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative anxiolytic that depresses the CNS, and brivaracetam can cause somnolence and dizziness. Combined use may cause marked drowsiness and impaired coordination.
How serious is the interaction between Brivaracetam and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and psychomotor impairment, particularly in older adults. Use the lowest effective meprobamate dose and avoid alcohol.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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