Drug interactions
Brivaracetam + Metoclopramide intranasal
Severity: Moderate
Brivaracetam and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness, dizziness and extrapyramidal effects, and it may lower the seizure threshold in some patients. Combined with an antiseizure drug, CNS adverse effects may be additive and seizure control could be affected.
What this interaction means in plain words
Brivaracetam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS effects; metoclopramide's central dopamine antagonism may lower seizure threshold.
What to do
Monitor for sedation, movement disorders and any change in seizure frequency. Consider a non-dopamine-blocking antiemetic if seizure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Brivaracetam and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness, dizziness and extrapyramidal effects, and it may lower the seizure threshold in some patients. Combined with an antiseizure drug, CNS adverse effects may be additive and seizure control could be affected.
How serious is the interaction between Brivaracetam and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, movement disorders and any change in seizure frequency. Consider a non-dopamine-blocking antiemetic if seizure control worsens.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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