Drug interactions
Brivaracetam + Midazolam intranasal
Severity: Moderate
Brivaracetam and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes dose-related CNS and respiratory depression, and brivaracetam adds sedative effects. The combination may increase the risk of hypoventilation and prolonged sedation.
What this interaction means in plain words
Brivaracetam and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant pharmacodynamic effects.
What to do
Monitor respiratory status and level of consciousness after midazolam administration, especially in patients on multiple sedating anticonvulsants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brivaracetam and Midazolam intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Midazolam intranasal?
MediHelp rates the interaction as moderate. Brivaracetam and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam causes dose-related CNS and respiratory depression, and brivaracetam adds sedative effects. The combination may increase the risk of hypoventilation and prolonged sedation.
How serious is the interaction between Brivaracetam and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory status and level of consciousness after midazolam administration, especially in patients on multiple sedating anticonvulsants.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
