Drug interactions
Brivaracetam + Nitrous oxide
Severity: Moderate
Brivaracetam and Nitrous oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrous oxide produces CNS depression and analgesia, and brivaracetam may add to drowsiness and dizziness. The effect may be more pronounced sedation during or after anesthesia or procedural sedation.
What this interaction means in plain words
Brivaracetam and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; nitrous oxide is an NMDA antagonist anesthetic and brivaracetam binds SV2A.
What to do
Monitor sedation level and vital signs during and after nitrous oxide use. Do not interrupt brivaracetam, and ensure full recovery before discharge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Nitrous oxide?
MediHelp rates the interaction as moderate. Brivaracetam and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrous oxide produces CNS depression and analgesia, and brivaracetam may add to drowsiness and dizziness. The effect may be more pronounced sedation during or after anesthesia or procedural sedation.
How serious is the interaction between Brivaracetam and Nitrous oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and vital signs during and after nitrous oxide use. Do not interrupt brivaracetam, and ensure full recovery before discharge.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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