Drug interactions
Brivaracetam + Orphenadrine
Severity: Moderate
Brivaracetam and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. With brivaracetam, sedation and cognitive impairment may be greater, especially in older patients.
What this interaction means in plain words
Brivaracetam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from anticholinergic and central effects of orphenadrine plus brivaracetam.
What to do
Monitor for sedation, confusion and falls, and use the lowest effective orphenadrine dose for the shortest time. Avoid in frail elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Orphenadrine?
MediHelp rates the interaction as moderate. Brivaracetam and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion. With brivaracetam, sedation and cognitive impairment may be greater, especially in older patients.
How serious is the interaction between Brivaracetam and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and falls, and use the lowest effective orphenadrine dose for the shortest time. Avoid in frail elderly patients where possible.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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