Drug interactions
Brivaracetam + Quazepam
Severity: Moderate
Brivaracetam and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic that causes sedation and psychomotor impairment, and brivaracetam adds to these effects. Residual next-day drowsiness and falls may be more likely.
What this interaction means in plain words
Brivaracetam and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and brivaracetam's SV2A-mediated effects.
What to do
Monitor for daytime sedation and falls, and use the lowest effective quazepam dose. Avoid alcohol and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Frequently asked questions
Can I take Brivaracetam with Quazepam?
MediHelp rates the interaction as moderate. Brivaracetam and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic that causes sedation and psychomotor impairment, and brivaracetam adds to these effects. Residual next-day drowsiness and falls may be more likely.
How serious is the interaction between Brivaracetam and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime sedation and falls, and use the lowest effective quazepam dose. Avoid alcohol and counsel on driving.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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