Drug interactions
Budesonide + Danazol
Severity: Moderate
Budesonide and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a CYP3A4 inhibitor and may raise budesonide exposure, increasing the risk of systemic corticosteroid effects with prolonged use.
What this interaction means in plain words
Budesonide and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated budesonide metabolism.
What to do
Monitor for Cushingoid features and adrenal suppression with long-term use, and consider a lower budesonide dose or alternative steroid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Danazol?
MediHelp rates the interaction as moderate. Budesonide and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a CYP3A4 inhibitor and may raise budesonide exposure, increasing the risk of systemic corticosteroid effects with prolonged use.
How serious is the interaction between Budesonide and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression with long-term use, and consider a lower budesonide dose or alternative steroid.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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