Drug interactions
Budesonide + Dichlorphenamide
Severity: Moderate
Budesonide and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use may produce additive hypokalemia. This is more relevant with systemic budesonide exposure, such as oral formulations or high doses, and may cause weakness or arrhythmias.
What this interaction means in plain words
Budesonide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive potassium loss: dichlorphenamide causes renal potassium wasting through carbonic anhydrase inhibition, and corticosteroids add mineralocorticoid-related kaliuresis.
What to do
Monitor serum potassium and bicarbonate at baseline and periodically during therapy. Replace potassium as needed and review the dichlorphenamide dose if hypokalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Budesonide with Dichlorphenamide?
MediHelp rates the interaction as moderate. Budesonide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use may produce additive hypokalemia. This is more relevant with systemic budesonide exposure, such as oral formulations or high doses, and may cause weakness or arrhythmias.
How serious is the interaction between Budesonide and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate at baseline and periodically during therapy. Replace potassium as needed and review the dichlorphenamide dose if hypokalemia develops.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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