Drug interactions
Budesonide + Diltiazem
Severity: Moderate
Budesonide and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem is a moderate CYP3A4 inhibitor and can increase systemic budesonide exposure. This raises the risk of corticosteroid-related adverse effects, mainly with oral budesonide.
What this interaction means in plain words
Budesonide and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Diltiazem belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 reduces budesonide metabolism.
What to do
Monitor for signs of corticosteroid excess such as Cushingoid features and adrenal suppression. Reduce the budesonide dose or choose an alternative if they develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Budesonide with Diltiazem?
MediHelp rates the interaction as moderate. Budesonide and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem is a moderate CYP3A4 inhibitor and can increase systemic budesonide exposure. This raises the risk of corticosteroid-related adverse effects, mainly with oral budesonide.
How serious is the interaction between Budesonide and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess such as Cushingoid features and adrenal suppression. Reduce the budesonide dose or choose an alternative if they develop.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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