Drug interactions
Budesonide + Erythromycin stearate
Severity: Moderate
Budesonide and Erythromycin stearate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can raise systemic budesonide exposure, increasing the risk of corticosteroid adverse effects. The effect is clinically relevant with oral or high-dose budesonide.
What this interaction means in plain words
Budesonide and Erythromycin stearate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated budesonide metabolism increases systemic exposure.
What to do
Monitor for signs of hypercortisolism and consider reducing the budesonide dose or choosing a non-macrolide antibiotic. Use the shortest effective duration of co-treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Erythromycin stearate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Erythromycin stearate?
MediHelp rates the interaction as moderate. Budesonide and Erythromycin stearate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits CYP3A4 and can raise systemic budesonide exposure, increasing the risk of corticosteroid adverse effects. The effect is clinically relevant with oral or high-dose budesonide.
How serious is the interaction between Budesonide and Erythromycin stearate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of hypercortisolism and consider reducing the budesonide dose or choosing a non-macrolide antibiotic. Use the shortest effective duration of co-treatment.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
