Drug interactions
Budesonide + Fenoprofen
Severity: Moderate
Budesonide and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with an NSAID increases the risk of gastrointestinal irritation, ulceration and bleeding. The risk is highest with systemic budesonide exposure, in older patients and with long-term use.
What this interaction means in plain words
Budesonide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury: NSAIDs inhibit protective prostaglandin synthesis while corticosteroids impair mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider adding a proton pump inhibitor in higher-risk patients. Counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Budesonide with Fenoprofen?
MediHelp rates the interaction as moderate. Budesonide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with an NSAID increases the risk of gastrointestinal irritation, ulceration and bleeding. The risk is highest with systemic budesonide exposure, in older patients and with long-term use.
How serious is the interaction between Budesonide and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider adding a proton pump inhibitor in higher-risk patients. Counsel patients to report black stools or abdominal pain.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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