Drug interactions
Budesonide + Human papillomavirus vaccine quadrivalent
Severity: Moderate
Budesonide and Human papillomavirus vaccine quadrivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given at above-physiologic systemic doses can blunt the antibody response to vaccines. The HPV vaccine may therefore produce a weaker or shorter-lived protective response in a patient on substantial systemic budesonide. Inhaled, topical or low-dose use is unlikely to matter clinically.
What this interaction means in plain words
Budesonide and Human papillomavirus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid-mediated immunosuppression reduces vaccine-induced B and T cell responses.
What to do
Where possible, give the vaccine series before starting prolonged systemic budesonide or at a time of lowest steroid dose; vaccination is not contraindicated as it is not a live vaccine. Do not delay the series for inhaled or low-dose therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Human papillomavirus vaccine quadrivalent?
MediHelp rates the interaction as moderate. Budesonide and Human papillomavirus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given at above-physiologic systemic doses can blunt the antibody response to vaccines. The HPV vaccine may therefore produce a weaker or shorter-lived protective response in a patient on substantial systemic budesonide. Inhaled, topical or low-dose use is unlikely to matter clinically.
How serious is the interaction between Budesonide and Human papillomavirus vaccine quadrivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine series before starting prolonged systemic budesonide or at a time of lowest steroid dose; vaccination is not contraindicated as it is not a live vaccine. Do not delay the series for inhaled or low-dose therapy.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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