Drug interactions
Budesonide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Budesonide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids and thiazides both lower potassium, increasing the risk of hypokalemia. The risk is lower with budesonide because of its high first-pass metabolism, but it rises with higher or prolonged dosing.
What this interaction means in plain words
Budesonide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide belongs to Respiratory; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting from thiazide and mineralocorticoid effect of corticosteroids.
What to do
Monitor serum potassium and replace potassium or magnesium if low. Be particularly watchful with systemic or high-dose budesonide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Budesonide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids and thiazides both lower potassium, increasing the risk of hypokalemia. The risk is lower with budesonide because of its high first-pass metabolism, but it rises with higher or prolonged dosing.
How serious is the interaction between Budesonide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and replace potassium or magnesium if low. Be particularly watchful with systemic or high-dose budesonide.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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