Drug interactions
Budesonide + Ibuprofen / famotidine
Severity: Minor
Budesonide and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which may cause pH-dependent oral budesonide formulations to release the drug prematurely. Absorption and local intestinal effect could change.
What this interaction means in plain words
Budesonide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased gastric pH disrupts the pH-dependent coating or release of enteric-coated and extended-release budesonide.
What to do
Monitor disease control. Consider whether acid suppression is needed, and separate administration where feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Budesonide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine raises gastric pH, which may cause pH-dependent oral budesonide formulations to release the drug prematurely. Absorption and local intestinal effect could change.
How serious is the interaction between Budesonide and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor disease control. Consider whether acid suppression is needed, and separate administration where feasible.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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