Drug interactions
Budesonide + Ketorolac intranasal
Severity: Moderate
Budesonide and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both corticosteroids and NSAIDs can injure the gastrointestinal mucosa, and combined use raises the risk of ulceration and bleeding. With locally acting budesonide and intranasal ketorolac, systemic exposure is low so the risk is small.
What this interaction means in plain words
Budesonide and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal toxicity from NSAID prostaglandin inhibition and corticosteroid effects.
What to do
Limit the duration of ketorolac and monitor for GI symptoms or bleeding; consider gastroprotection in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Budesonide and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both corticosteroids and NSAIDs can injure the gastrointestinal mucosa, and combined use raises the risk of ulceration and bleeding. With locally acting budesonide and intranasal ketorolac, systemic exposure is low so the risk is small.
How serious is the interaction between Budesonide and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of ketorolac and monitor for GI symptoms or bleeding; consider gastroprotection in patients at high GI risk.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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