Drug interactions
Budesonide + Measles mumps rubella and varicella vaccine live
Severity: Major
Budesonide and Measles mumps rubella and varicella vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live combination vaccine may cause disseminated vaccine-strain infection, particularly varicella, in patients immunosuppressed by corticosteroids. Immune response may also be reduced.
What this interaction means in plain words
Budesonide and Measles mumps rubella and varicella vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid suppression of cell-mediated immunity impairs control of live attenuated viruses.
What to do
Avoid during immunosuppressive budesonide dosing; delay vaccination until steroid therapy has been stopped for the labeled interval.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Measles mumps rubella and varicella vaccine live?
MediHelp rates the interaction as major. Budesonide and Measles mumps rubella and varicella vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This live combination vaccine may cause disseminated vaccine-strain infection, particularly varicella, in patients immunosuppressed by corticosteroids. Immune response may also be reduced.
How serious is the interaction between Budesonide and Measles mumps rubella and varicella vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during immunosuppressive budesonide dosing; delay vaccination until steroid therapy has been stopped for the labeled interval.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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