Drug interactions
Budesonide + Metronidazole
Severity: Minor
Budesonide and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has weak and inconsistent CYP3A4 inhibition, so any rise in budesonide exposure is likely small. Clinical significance is limited but systemic corticosteroid effects could be slightly increased with oral budesonide.
What this interaction means in plain words
Budesonide and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide belongs to Respiratory; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP3A4-mediated budesonide metabolism.
What to do
No dose adjustment is usually needed; monitor for corticosteroid adverse effects during prolonged co-administration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Budesonide
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Budesonide with Metronidazole?
MediHelp rates the interaction as minor. Budesonide and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has weak and inconsistent CYP3A4 inhibition, so any rise in budesonide exposure is likely small. Clinical significance is limited but systemic corticosteroid effects could be slightly increased with oral budesonide.
How serious is the interaction between Budesonide and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for corticosteroid adverse effects during prolonged co-administration.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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