Drug interactions
Budesonide + Nafcillin
Severity: Moderate
Budesonide and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may reduce budesonide concentrations. Reduced efficacy of budesonide could occur, especially with oral formulations that rely on extensive first-pass metabolism.
What this interaction means in plain words
Budesonide and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nafcillin induces CYP3A4, increasing budesonide metabolism.
What to do
Monitor clinical response to budesonide during and after nafcillin therapy and adjust the dose if disease control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Nafcillin?
MediHelp rates the interaction as moderate. Budesonide and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may reduce budesonide concentrations. Reduced efficacy of budesonide could occur, especially with oral formulations that rely on extensive first-pass metabolism.
How serious is the interaction between Budesonide and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to budesonide during and after nafcillin therapy and adjust the dose if disease control worsens.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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