Drug interactions
Budesonide + Phenindione
Severity: Moderate
Budesonide and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can unpredictably alter the response to oral anticoagulants, with reports of both reduced and increased anticoagulation. Systemic exposure from budesonide is low, so the effect is generally modest but possible with higher doses.
What this interaction means in plain words
Budesonide and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; corticosteroids may alter coagulability and vascular integrity.
What to do
Check INR more frequently when starting, changing or stopping budesonide and adjust phenindione dosing accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide and Phenindione, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Phenindione?
MediHelp rates the interaction as moderate. Budesonide and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can unpredictably alter the response to oral anticoagulants, with reports of both reduced and increased anticoagulation. Systemic exposure from budesonide is low, so the effect is generally modest but possible with higher doses.
How serious is the interaction between Budesonide and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more frequently when starting, changing or stopping budesonide and adjust phenindione dosing accordingly.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
