Drug interactions
Budesonide + Salicylates
Severity: Moderate
Budesonide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining corticosteroids with salicylates increases the risk of gastric irritation, ulceration and bleeding. Corticosteroids may also lower salicylate levels. The risk is lower with budesonide than with systemic steroids.
What this interaction means in plain words
Budesonide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from corticosteroid effects and salicylate prostaglandin inhibition.
What to do
Monitor for GI bleeding symptoms and consider gastroprotection in patients at higher risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Salicylates?
MediHelp rates the interaction as moderate. Budesonide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining corticosteroids with salicylates increases the risk of gastric irritation, ulceration and bleeding. Corticosteroids may also lower salicylate levels. The risk is lower with budesonide than with systemic steroids.
How serious is the interaction between Budesonide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding symptoms and consider gastroprotection in patients at higher risk.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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