Drug interactions
Budesonide + Salsalate
Severity: Moderate
Budesonide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID, and combined use with a corticosteroid increases the risk of gastrointestinal ulceration and bleeding. Risk is lower with budesonide than with systemic steroids.
What this interaction means in plain words
Budesonide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury from corticosteroid effects and salicylate prostaglandin inhibition.
What to do
Use the lowest effective doses, consider a proton pump inhibitor in at-risk patients and monitor for GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Salsalate?
MediHelp rates the interaction as moderate. Budesonide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID, and combined use with a corticosteroid increases the risk of gastrointestinal ulceration and bleeding. Risk is lower with budesonide than with systemic steroids.
How serious is the interaction between Budesonide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses, consider a proton pump inhibitor in at-risk patients and monitor for GI bleeding.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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