Drug interactions
Budesonide + Typhoid vaccine live
Severity: Major
Budesonide and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine contains replicating attenuated bacteria, and corticosteroid immunosuppression may permit disseminated infection and reduce vaccine efficacy. The risk is mainly with systemic or high-dose budesonide.
What this interaction means in plain words
Budesonide and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Glucocorticoid-induced immunosuppression impairs control of the live attenuated organism and the vaccine response.
What to do
Avoid the live oral vaccine in patients on immunosuppressive steroid doses and use the inactivated polysaccharide vaccine instead. Delay live vaccination until steroids are stopped for the labeled interval.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide
Frequently asked questions
Can I take Budesonide with Typhoid vaccine live?
MediHelp rates the interaction as major. Budesonide and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Live oral typhoid vaccine contains replicating attenuated bacteria, and corticosteroid immunosuppression may permit disseminated infection and reduce vaccine efficacy. The risk is mainly with systemic or high-dose budesonide.
How serious is the interaction between Budesonide and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live oral vaccine in patients on immunosuppressive steroid doses and use the inactivated polysaccharide vaccine instead. Delay live vaccination until steroids are stopped for the labeled interval.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
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